3 years ago

Optimization of pre‐analytical heat treatment for inhibitor detection in haemophilia A

Factor VIII (FVIII) antibody formation is the greatest clinical and laboratory challenge within the haemophilia centre. The Nijmegen‐Bethesda assay (NBA) is the gold standard for inhibitor quantification, but affected by pre‐analytical variables including a patient’s FVIII activity (FVIII:C). Pre‐analytical heat treatment (PHT) provides a methodology for inhibitor testing when measurable FVIII:C is present.
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