3 years ago

pH-Triggered release of an antifungal agent from polyglycidol-based nanoparticles against fuel fungus H. resinae

pH-Triggered release of an antifungal agent from polyglycidol-based nanoparticles against fuel fungus H. resinae
Valérie Héroguez, Joanne Fernandez, Mehdi Neqal, Mario Gauthier, Véronique Coma
The goal of this investigation was the development of smart plurifunctional polymeric particles able to deliver a biocide following an acidic trigger due to the presence of microorganisms. Such particles were synthesized by Ring-Opening Metathesis Polymerization of an α-norbornenyl polyglycidol macromonomer functionalized with biocide through a pH-sensitive imine bond. H. resinae was selected as a target strain. In the first part, the pH sensitivity of the functionalized particles was studied. Then, the antifungal activity of both the biocide-functionalized macromonomer and the functionalized particles was evaluated. Incorporation of the particles in a commercial model coating was also tested, to verify that its original barrier properties were maintained.
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