Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Cover Picture: Magnesium-Catalyzed Electrophilic Trifluoromethylation: Facile Access to All-Carbon Quaternary Centers in Oxindoles (Chem. Eur. J. 35/2017)

Cover Picture: Magnesium-Catalyzed Electrophilic Trifluoromethylation: Facile Access to All-Carbon Quaternary Centers in Oxindoles (Chem. Eur. J. 35/2017)
Dmitry Katayev, Harutake Kajita, Antonio Togni
A magnesium salt is capable of activating electrophilic hypervalent iodine reagents and thereby catalyzing the first direct trifluoromethylation of 3-substituted oxindoles. This synthetically important transformation leads to the formation of challenging perfluoroalkylated quaternary carbon centers under very mild reaction conditions and demonstrates excellent functional group tolerance. Such a unique activation mode by magnesium salts opens new avenues for discovering novel perfluoroalkylation methodologies. More information can be found in the Communication by D. Katayev et al. on page 8353.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701336

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