3 years ago

Control of Reversible Activation Dynamics of [Ru{η6:κ1-C6H5(C6H4)NH2}(XY)]n+ and the Effect of Chelating-Ligand Variation

Control of Reversible Activation Dynamics of [Ru{η6:κ1-C6H5(C6H4)NH2}(XY)]n+ and the Effect of Chelating-Ligand Variation
Ana M. Pizarro, Francisco Martínez-Peña
The design of organometallic pH-dependent switches to control in-tumor drug activation is presented. In this picture, the middle and background show that inactive ruthenium(II) arene complexes are innocuous (represented in blue), locked away inside boxes, unable to interact with their molecular target. It is shown, however, that protons (represented by the keys) can open the boxes and release the active form of the ruthenium drug (in red, with Ru in metallic grey), which can bind to DNA. The potential of a series of ruthenium(II) complexes to become pH-responsive anticancer drugs is thus demonstrated. More information can be found in the Full Paper by A. M. Pizarro and F. Martínez-Peña (DOI: 10.1002/chem.201701681).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201703853

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