5 years ago

Determination of the Absolute Configuration of (−)-Hydroxynitrilaphos and Related Biosynthetic Questions

Determination of the Absolute Configuration of (−)-Hydroxynitrilaphos and Related Biosynthetic Questions
Katharina Pallitsch, Christian Stieger, Barbara Happl
The fascinating enzymology involved in phosphonate metabolism often seems as complex as if it involved some kind of magic. Extraordinary enzymes are identified at a rapid pace and experience has taught us that seemingly simple reactions often involve very complex transformations in phosphonate biochemistry. While the possible substrate (2-amino-1-hydroxyethylphosphonic acid=2-AEP) and cofactors (Fe2+) necessary for hydroxynitrilaphos biosynthesis were already suggested, we have now determined the stereochemical course of this unusual transformation. However, the reaction intermediates and exact mechanism remain elusive. More information can be found in the Full Paper by K. Pallitsch et al. (DOI: 10.1002/chem.201702904).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201703496

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