3 years ago

Enantioselective Synthesis of Cyclobutenes by Intermolecular [2+2] Cycloaddition with Non-C2 Symmetric Digold Catalysts

Enantioselective Synthesis of Cyclobutenes by Intermolecular [2+2] Cycloaddition with Non-C2 Symmetric Digold Catalysts
Andrey I. Konovalov, Beatrice Ranieri, Imma Escofet, Antonio M. Echavarren, Carla Obradors, Laura López-Suarez, Cristina García-Morales
The enantioselective intermolecular gold(I)-catalyzed [2+2] cycloaddition of terminal alkynes and alkenes has been achieved using non-C2-chiral Josiphos digold(I) complexes as catalysts, by the formation of the monocationic complex. This new approach has been applied to the enantioselective total synthesis of rumphellaone A.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b07651

DOI: 10.1021/jacs.7b07651

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