Organic Letters
Organic Letters
5 years ago

A Tandem Oxidative Annulation Strategy for the Synthesis of Tetracyclic 3-Spirooxindole Benzofuranones

A Tandem Oxidative Annulation Strategy for the Synthesis of Tetracyclic 3-Spirooxindole Benzofuranones
Min Liu, Hao Xie, Mingruo Ding, Chunxia Zhang, Fengzhi Zhang
A simple and efficient method was developed for the construction of the medicinally important tetracyclic 3-spirooxindole benzofuranones. In this highly atom- and step-economical one-pot protocol, one quaternary carbon center, two new cycles, and four new bonds (C–C/C–O/C–N) were formed under simple ligand-free copper-catalyzed conditions through a novel tandem oxidative annulation strategy.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01374

DOI: 10.1021/acs.orglett.7b01374

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