3 years ago

The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome

The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
Dinora Lopes, José Pedro Gil, António Sebastião Rodrigues, Virgílio do Rosário, Kinanga Kiaco
Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.
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