4 years ago

Catalytic Conjugate Addition of Electron-Rich Heteroarenes to β,β-Disubstituted Enones

Catalytic Conjugate Addition of Electron-Rich Heteroarenes to β,β-Disubstituted Enones
Tanner L. Metz, Joshua Evans, Levi M. Stanley
Catalytic conjugate additions of heteroarenes to β,β-disubstituted enones are reported. Additions of a range of heteroarene nucleophiles, including furans, indoles, a pyrrole, and a thiophene, to a variety of β,β-disubstituted enones occur to form the corresponding ketone products containing heteroarylated, all-carbon quaternary centers in up to 90% yield. These reactions occur under mild reaction conditions in the presence of low loadings of bismuth triflate.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01402

DOI: 10.1021/acs.orglett.7b01402

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