3 years ago

Frontispiece: Tandem Oxidative Derivatization of Nitrene Insertion Products for the Highly Diastereoselective Synthesis of 1,3-aminoalcohols

Frontispiece: Tandem Oxidative Derivatization of Nitrene Insertion Products for the Highly Diastereoselective Synthesis of 1,3-aminoalcohols
Juliet M. Alderson, Jennifer M. Schomaker
A tandem reaction sequence for the highly diastereoselective synthesis of 1,3-aminoalcohols has been developed. These important motifs are present in many biologically active natural products and pharmaceuticals, but few methods allow for access to products containing a chiral alpha-tertiary amine. This three-step protocol features a tandem silver-catalyzed C–H nitrene transfer reaction and amine-to-imine oxidation, followed by stereocontrolled addition of a nucleophile to the intermediate imine. For more information, see Communication by Jennifer M. Schomaker et al. on page 8571 ff.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201783662

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