Chemical Communications
Chemical Communications
5 years ago

Distinguishing D- and L-aspartic and isoaspartic acids in amyloid [small beta] peptides with ultrahigh resolution ion mobility spectrometry

Distinguishing D- and L-aspartic and isoaspartic acids in amyloid [small beta] peptides with ultrahigh resolution ion mobility spectrometry
Yehia M. Ibrahim, Erin S. Baker, Liulin Deng, Richard D. Smith, Vladislav A. Petyuk, Xueyun Zheng
Ion mobility spectrometry (IMS) was utilized to separate A[small beta] peptide variants containing isomeric asparic and isoaspartic acid residues with either a L- or D-form. The abundance of each variant is of great interest in Alzheimer's disease studies and also to evaluate how often these modifications are occurring in other environmental and biological samples.

Publisher URL: http://feeds.rsc.org/~r/rss/CC/~3/nf1zLSQrymQ/C7CC03321D

DOI: 2017/CC/C7CC03321D

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