Organic Letters
Organic Letters
5 years ago

Copper-Catalyzed Borylative Cyclization of in Situ Generated o-Allenylaryl Nitriles with Bis(pinacolato)diboron

Copper-Catalyzed Borylative Cyclization of in Situ Generated o-Allenylaryl Nitriles with Bis(pinacolato)diboron
Xin Xie, Yuanhong Liu, Meijun Xiong
A Cu-catalyzed cascade borylcupration/cyclization of in situ generated allene-nitriles with B2pin2 has been developed, which provides highly substituted 3-boryl-1-naphthylamines with excellent regioselectivity and wide functional group compatibility. It has been shown that, for the first time, the catalytically generated allylcopper species can be captured by a cyano group from a normal nitrile to furnish a carbocycle.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01355

DOI: 10.1021/acs.orglett.7b01355

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