Journal of Organic Chemistry
Journal of Organic Chemistry
4 years ago

Palladium-Catalyzed Desulfitative Cross-Coupling of Arylsulfonyl Hydrazides with Terminal Alkynes: A General Approach toward Functionalized Internal Alkynes

Palladium-Catalyzed Desulfitative Cross-Coupling of Arylsulfonyl Hydrazides with Terminal Alkynes: A General Approach toward Functionalized Internal Alkynes
Shuang-Feng Yin, Yongbo Zhou, Liang-Wei Qian, Jianyu Dong, Mengli Sun, Qing Xu
A palladium-catalyzed Sonogashira-type coupling between arylsulfonyl hydrazides and terminal alkynes via Ar(C)–S bond cleavage is disclosed, which enables the general synthesis of functionalized internal alkynes, especially the Br-substituted ones, in good to excellent yields under acid- and base-free conditions.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00899

DOI: 10.1021/acs.joc.7b00899

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