3 years ago

Complexity and function of NKT cells with potential application to hepatic transplant survival.

Kumar V, Ware R
One of the major innate-like lymphocyte populations enriched in liver consists of Natural Killer T (NKT) cells, which recognize self and foreign lipid antigens presented by the non-polymorphic class I MHC-like molecule CD1d. NKT cells express NK cell markers as well as T cell receptors (TCR) and can be classified into 2 categories: type I NKT cells use a semi-invariant TCR whereas type II NKT cells express diverse but still limited TCRs. An emerging body of evidence points to their opposing roles in inflammation, including ischemic reperfusion injury. Improved understanding of their roles in experimental models as well as as in humans and the means by which their function can be manipulated may provide therapeutic benefit in liver diseases and in organ transplantation. This article is protected by copyright. All rights reserved.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28945950

DOI: PubMed:28945950

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