Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Construction of β-Trifluoromethyl Enol Ether via Base-Promoted C–O Coupling and Rearrangement of Hydrogen Atom

Construction of β-Trifluoromethyl Enol Ether via Base-Promoted C–O Coupling and Rearrangement of Hydrogen Atom
Kuan Wang, Jian-Gang Chen, Kun Dai, Zhong-Wen Liu, Jian Lu, Yang Li, Zhao-Tie Liu
A novel, high-efficiency and high-selectivity construction of β-trifluoromethyl enol ether via base-induced/promoted C–O coupling of trifluoromethylated vinyl chloride and phenols is presented with a broad substrate scope. The reaction mechanism, especially the significantly high selectivity, was excavated and understood via DFT calculation and is well supported by the experimental observation.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00396

DOI: 10.1021/acs.joc.7b00396

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