Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
5 years ago

Genomic Characterization of Two KPC-Producing Klebsiella Isolates Collected in 1997 in New York City.

Chavda KD, Kreiswirth BN, Eilertson B, Chen L
Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have now become a global public health threat. However, the origin of this pandemic and the characterization of pre-2003 blaKPC-harboring plasmids remain unknown. Here we used next-generation sequencing to characterize two KPC-2-producing K. pneumoniae and Kmichiganensis isolates collected from a New York City hospital in 1997. Although identified in two different Klebsiella species, the blaKPC-2 gene was harbored by Tn4401b transposons on two highly similar IncN plasmids.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28167551

DOI: PubMed:28167551

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