3 years ago

Characterization of β-d-N(4)-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.

Russell OO, Jiang Y, Hsiao HM, Amblard F, Hammond E, Merits A, Zandi K, Tao S, Ehteshami M, Schinazi RF
Chikungunya virus (CHIKV) represents a reemerging global threat to human health. Recent outbreaks across Asia, Europe, Africa, and the Caribbean have prompted renewed scientific interest in this mosquito-borne alphavirus. There are currently no vaccines against CHIKV, and treatment has been limited to nonspecific antiviral agents, with suboptimal outcomes. Herein, we have identified β-d-N4-hydroxycytidine (NHC) as a novel inhibitor of CHIKV. NHC behaves as a pyrimidine ribonucleoside and selectively inhibits CHIKV replication in cell culture.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28137799

DOI: PubMed:28137799

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