5 years ago

Stereodivergent synthesis with a programmable molecular machine

Stereodivergent synthesis with a programmable molecular machine
Simone Pisano, Salma Kassem, David A. Leigh, Leoni I. Palmer, Vanesa Marcos, Alan T. L. Lee

It has been convincingly argued1, 2, 3 that molecular machines that manipulate individual atoms, or highly reactive clusters of atoms, with Ångström precision are unlikely to be realized. However, biological molecular machines routinely position rather less reactive substrates in order to direct chemical reaction sequences, from sequence-specific synthesis by the ribosome4 to polyketide synthases5, 6, 7, where tethered molecules are passed from active site to active site in multi-enzyme complexes. Artificial molecular machines8, 9, 10, 11, 12 have been developed for tasks that include sequence-specific oligomer synthesis13, 14, 15 and the switching of product chirality16, 17, 18,

Publisher URL: http://dx.doi.org/10.1038/nature23677

DOI: 10.1038/nature23677

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