3 years ago

NAFLD: PNPLA3 and obesity: a synergistic relationship in NAFLD

Jake P. Mann, Quentin M. Anstee

NAFLD, the hepatic manifestation of the metabolic syndrome, is a multifactorial condition — environmental factors influence an inherited genetic risk. Stender et al. now describe the additive effect of obesity and NAFLD-associated genetic polymorphisms on steatosis, elevated serum alanine aminotransferase levels and cirrhosis, remarkably illustrating the principle of gene–environment interactions.

Publisher URL: http://dx.doi.org/10.1038/nrgastro.2017.74

DOI: 10.1038/nrgastro.2017.74

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