New insight into the control of peptic ulcer by targeting the histamine H2 receptor

5 years ago

New insight into the control of peptic ulcer by targeting the histamine H2 receptor

Nisarg Gohil, Vijai Singh, Robert Ramírez-García

Peptic ulcer disease is one of the major challenges in public health globally and new evidence shows that it can be controlled by targeting the histamine H2 receptor (H2R). Recently, a number of H2R antagonists have been synthesized and used to block the action of histamine on the parietal cells in the stomach and decrease the acid production. In this study, we modeled the H2R by homology modeling using the 3-D crystal structure and this model was validated based on free energy and amino acid residues present in the allowed regions of a Ramachandran plot. We used this 3-D model for screening of highly potent drugs using molecular docking. We found cimetidine, cimetex, and famotidine as the most potent drugs based on the binding affinity of drug-protein interactions. We also generated a cellular network for H2R that could be useful for better understanding of cellular mechanism and drug targets. These findings provide a new insight into the development of suitable, specific, and effective anti-ulcer drugs for a most effective treatment of ulcerous diseases. Peptic ulcer disease is one of the major obstacle of public health globally. A number of histamine H2 receptor antagonists drugs have been used to block the action of histamine on parietal cells in the stomach and decrease the acid production. We have generated the 3-D model based on known 3-D crystal structure and used this model for screening of suitable, effective, and potent anti-ulcer drugs.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jcb.26361