Organic Letters
Organic Letters
5 years ago

Photoredox Catalysis: Construction of Polyheterocycles via Alkoxycarbonylation/Addition/Cyclization Sequence

Photoredox Catalysis: Construction of Polyheterocycles via Alkoxycarbonylation/Addition/Cyclization Sequence
Xinxin Fang, Shengyi Zhuang, Peipei Sun, Ping Liu, Xuanxuan Li
A novel visible-light-induced cascade reaction for the preparation of ester-functionalized polyheterocycles was developed under metal-free conditions, which was initiated by an intermolecular radical addition to a carbon–carbon double bond of N-arylacrylamide derivatives using alkyl carbazate as the ester source followed by cyano-mediated cyclization. The desired phenanthridine derivative products were isolated in moderate to high yields with broad substrate scope.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01553

DOI: 10.1021/acs.orglett.7b01553

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