3 years ago

Biosynthesis: SAM cycles up for colibactin

Biosynthesis: SAM cycles up for colibactin
Steven G Van Lanen

The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.

Publisher URL: http://dx.doi.org/10.1038/nchembio.2479

DOI: 10.1038/nchembio.2479

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