Genome mining: Digging the tunnel for chemical space
Genome mining reveals a new ribosomally synthesized and post-translationally modified peptide (RiPP) from Klebsiella pneumoniae. This new antibiotic inhibits bacterial ribosomes by obstructing the peptide exit tunnel, and its modular nature presents a unique opportunity for future engineering of antibacterial drugs.
Publisher URL: http://dx.doi.org/10.1038/nchembio.2480
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