Journal of Organic Chemistry
Journal of Organic Chemistry
4 years ago

Total Synthesis of Pestalotioprolide G and Putative Structure of Pestalotioprolide H

Total Synthesis of Pestalotioprolide G and Putative Structure of Pestalotioprolide H
Rajib Kumar Goswami, Sayantan Das, Debobrata Paul
A concise and convergent route for the stereoselective total synthesis of cytotoxic macrolides pestalotioprolides G and H has been developed for the first time. Intramolecular Heck coupling has been chosen to cyclize the 14-membered macrocycle. This synthetic study strongly suggests that the proposed structure of pestalotioprolide H may need to be corrected as the spectroscopic data on the synthesized molecule deviate from the values reported for the isolated natural product.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01115

DOI: 10.1021/acs.joc.7b01115

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