Organic Letters
Organic Letters
5 years ago

Copper-Catalyzed Regio- and Stereoselective Iodocyanation and Dicyanation of Alkynes with Cyanogen Iodide

Copper-Catalyzed Regio- and Stereoselective Iodocyanation and Dicyanation of Alkynes with Cyanogen Iodide
Kazuhiro Okamoto, Gaku Matsushita, Naoki Sakata, Kouichi Ohe, Kohei Sasakura
anti-Selective iodocyanation and dicyanation of various internal alkynes has been developed by means of a simple copper catalyst system. The selectivity of the products was switched by tuning the reaction conditions. Mechanistic studies have revealed all of the stepwise pathways including diiodide formation, selective monocyanation, and second cyanation processes.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01378

DOI: 10.1021/acs.orglett.7b01378

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