Organic Letters
Organic Letters
5 years ago

Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions

Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions
Lena Huck, Angel Díaz-Ortiz, Antonio de la Hoz, Jesus Alcázar
An on-demand preparation of organomagnesium reagents is presented using a new flow protocol. The risks associated with the activation of magnesium are circumvented by a new on-column initiation procedure. Required amounts of solutions with a precise titration were obtained. Telescoped flow or batch reactions allow access to a diverse set of functional groups.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01590

DOI: 10.1021/acs.orglett.7b01590

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