3 years ago

Right ventricular function during pharmacological and exercise stress testing in horses

The disproportionate rise of pulmonary artery pressure compared to systemic blood pressure during exercise can lead to detrimental right ventricular remodelling in endurance athletes. Horses may act as an extreme model of these athletic cardiovascular adaptations, as they show a three fold increase in pulmonary pressures during exercise. Right ventricular function was examined in ten healthy horses using post-exercise and pharmacological stress echocardiography in a randomised cross-over design. Exercise testing was performed on a treadmill while pharmacological testing was performed using an atropine-dobutamine infusion. Heart rate, systemic blood pressure and cardiac output during echocardiography were similar post-exercise compared to maximal pharmacological stress. Systolic pulmonary artery pressure was significantly higher during the exercise test (121±15mmHg) and during immediate post-exercise echocardiography (93±10mmHg) compared to maximal pharmacological stress (69±12mmHg). Right ventricular diameters as well as the ratio of systolic right to left ventricular area were higher post-exercise. Right ventricular fractional area change was significantly decreased post-exercise (40.5±6.2%) compared to a significant increase during pharmacological stress echocardiography (72.6±7.3%). Serum cardiac troponin I concentration was significantly higher 2h after the pharmacological test compared to baseline values and post-exercise, although the highest value was found post-exercise in the horse with the highest systolic pulmonary artery pressure and lowest right ventricular fractional area change. Pharmacological stress testing is not recommended in further studies on right ventricular adaptations in athletic horses, as this does not reproduce the effects of exercise.

Publisher URL: www.sciencedirect.com/science

DOI: S1090023317301521

You might also like
Never Miss Important Research

Researcher is an app designed by academics, for academics. Create a personalised feed in two minutes.
Choose from over 15,000 academics journals covering ten research areas then let Researcher deliver you papers tailored to your interests each day.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.