3 years ago

Dynamic Docking and Undocking Processes Addressing Selectively the Outside and Inside of Polymersomes

Dynamic Docking and Undocking Processes Addressing Selectively the Outside and Inside of Polymersomes
Petr Formanek, Brigitte Voit, Silvia Moreno, Dietmar Appelhans, Jörg Kluge, Banu Iyisan, Hannes Gumz, Anna Charlott Siedel, Jens Gaitzsch, Mohamed Yassin
Increasing complexity and diversity of polymersomes and their compartments is a key issue for mimicking cellular functions and protocells. Thus, new challenges arise in terms of achieving tunable membrane permeability and combining it with control over the membrane diffusion process, and thus enabling a localized and dynamic control of functionality and docking possibilities within or on the surface of polymeric compartments. This study reports the concept of polymersomes with pH-tunable membrane permeability for controlling sequential docking and undocking processes of small molecules and nanometer-sized protein mimics selectively on the inside and outside of the polymersome membrane as a further step toward the design of intelligent multifunctional compartments for use in synthetic biology and as protocells. Host–guest interactions between adamantane and β-cyclodextrin as well as noncovalent interactions between poly(ethylene glycol) tails and β-cyclodextrin are used to achieve selective and dynamic functionalization of the inner and outer spheres of the polymersome membrane. Dynamic docking and undocking processes are performed by the use of functional and pH-responsive polymersomes that allow for incorporating nanometer-sized entities selectively at the inner and outer spheres of the membrane through noncovalent interactions. This versatile concept can open up a new way for the design of intelligent nanoreactors with high complexity and diversity.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/marc.201700486

You might also like
Never Miss Important Research

Researcher is an app designed by academics, for academics. Create a personalised feed in two minutes.
Choose from over 15,000 academics journals covering ten research areas then let Researcher deliver you papers tailored to your interests each day.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.