3 years ago

Progress and Challenges Towards Point-of-Care Diagnostic Development for Dengue.

Dengue detection strategies involve viral RNA, antigen and/or antibody detection. Each strategy has its advantages and disadvantages. Optimal, user-friendly and rapid diagnostic tests based on immunochromatographic assays are pragmatic point-of-care-test (POCT) in dengue endemic regions where there are limited laboratory capabilities and optimal storage conditions. Increasingly, there is a greater public health significance for multiplexing assay to differentiate dengue from Zika or pathogens with similar clinical presentations. Although there have been much assay/platform developments towards POCT, independent validation and implementation remain very limited. This review highlights the current key progress and challenges towards the development of dengue POCT.

Publisher URL: http://doi.org/10.1128/JCM.00707-17

DOI: 10.1128/JCM.00707-17

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