3 years ago

Optimization of the Synthesis of Flavone–Amino Acid and Flavone–Dipeptide Hybrids via Buchwald–Hartwig Reaction

Optimization of the Synthesis of Flavone–Amino Acid and Flavone–Dipeptide Hybrids via Buchwald–Hartwig Reaction
Petr Džubák, Krisztina Kónya, György Panyi, Zoltán Pethő, Dávid Pajtás, Tamás Patonay, Attila Kiss-Szikszai, Zoltán Varga
The article describes the development of Buchwald–Hartwig amination of different bromoflavones with amino acid and peptide derivatives as nitrogen source giving unique structures. The previously observed racemization, which occurred during the synthesis of flavone-amino acid hybrids, was successfully prevented in most cases. The biological assays of these novel structures showed cytotoxic effects on different cancer cell lines.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00124

DOI: 10.1021/acs.joc.7b00124

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