4 years ago

Emerging Roles of Inflammasomes in Acute Pneumonia.

Pneumonia is responsible for a substantial burden on healthcare worldwide and the single largest cause for death of infants globally. Pneumonia is caused by a variety of pathogenic microorganisms including bacteria, viruses and fungi. The lung has developed complex innate immune mechanisms to combat these infections while minimizing tissue damage. One essential mechanism that drives the initial innate immune response is sensing a broad spectrum of stimuli in the cytosol by inflammasomes. Inflammasomes are composed of NLR and non-NLR proteins, and activate caspase-1 that results in proinflammatory cytokine activation. When insufficiently controlled, inflammasome activation in the lung leads to extensive inflammation and excessive tissue damage. The aim of this review is to highlight recent advances that illuminate on the roles of inflammasomes and their signaling cascades in acute microbial pneumonia. We also discuss unanswered questions and current controversies associated with inflammasome functions and implications in acute pneumonia. Ultimately, understanding the molecular and cellular mechanisms associated with inflammasome signaling in the lung is potentially important for the development of novel and effective strategies to control pneumonia, and its associated pathologies and the untoward consequences of unchecked inflammation.

Publisher URL: http://doi.org/10.1164/rccm.201707-1391PP

DOI: 10.1164/rccm.201707-1391PP

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.