3 years ago

Irritable bowel syndrome in Asia: pathogenesis, natural history, epidemiology and management.

Historically, the epidemiology of gastrointestinal diseases in Asia was different from that in Western countries. Early studies suggested a low prevalence of irritable bowel syndrome (IBS) in Asia. As the diagnosis of IBS is symptom-based, and as symptom perception, expression and interpretation, are influenced by sociocultural perspectives including language, the presentation of IBS is expected to vary in different communities. Furthermore, the pathogenesis is multifactorial with psychosocial (stress, illness, behavior, diet) and biological (infection, gut microbiota, immune activation) variables interacting, and so we can anticipate that the development of IBS will vary in different environments. In recognition of this aspect of functional GI disorders, the recently published Rome IV documents have provided greater focus on cross-cultural factors. In this review, we seek to highlight Asian perspectives by identifying historical trends and recent publications from the region, and comparing these with the observations from Western societies.

Publisher URL: http://doi.org/10.1111/jgh.13987

DOI: 10.1111/jgh.13987

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