Journal of the American Chemical Society
Journal of the American Chemical Society
5 years ago

Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes

Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes
Beatrice S. L. Collins, Varinder K. Aggarwal, James R. Smith, Eddie L. Myers, Mark A. Graham, Matthew J. Hesse
We report the first enantioselective Rh-catalyzed Markovnikov hydroboration of unactivated terminal alkenes. Using a novel sp2–sp3 hybridized diboron reagent and water as a proton source, a broad range of alkenes undergo hydroboration to provide secondary boronic esters with high regio- and enantiocontrol.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b05149

DOI: 10.1021/jacs.7b05149

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