ACS Nano
ACS Nano
5 years ago

Disassembly of Dipeptide Single Crystals Can Transform the Lipid Membrane into a Network

Disassembly of Dipeptide Single Crystals Can Transform the Lipid Membrane into a Network
Qi Li, Meifang Fu, Bingbing Sun, Luru Dai, Junbai Li, Yang Yang, Tommy Nylander
Coupling between cytoskeleton and membranes is critical to cell movement as well as organelle formation. Here, we demonstrate that self-assembled single crystals of a dipeptide, diphenylalanine (FF), can interact with liposomes to form cytoskeleton-like structures. Under a physiological condition, disassembly of FF crystals deforms and translocates supported lipid membrane. The system exhibits similar dynamic characteristics to the endoplasmic reticulum (ER) network in cells. This bottom-up system thus indicates that external matter can participate in the deformation of liposomes, and disassembly of the nanostructures enables a system with distinct dynamic behaviors.

Publisher URL: http://dx.doi.org/10.1021/acsnano.7b03468

DOI: 10.1021/acsnano.7b03468

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