3 years ago

Real-world effect of ribavirin on quality of life in HCV-infected patients receiving interferon-free treatment

Markus Cornberg, Kerstin Port, Heiner Wedemeyer, Philipp Solbach, Christoph Höner zu Siederdissen, Katja Deterding, Bernhard Schlevogt, Michael P. Manns
Background Ribavirin (RBV) is commonly used for the treatment of hepatitis C virus (HCV) infection. However, RBV is associated with a reduced quality of life (QOL). We aim to assess the impact of RBV on QOL in a real-world setting. Methods In a prospective study, QOL was measured by a SF-36 questionnaire in 174 patients. 85 patients were treated with RBV and 89 patients without RBV. QOL was assessed at baseline, week 12 of treatment and 24 weeks after treatment. Results Patients treated with RBV were more likely to have HCV genotype 2 and 3 infection and cirrhosis (all p < 0.05). RBV treated patients reported lower scores for several domains of QOL already at baseline. During HCV treatment RBV-free treatment led to an increase in all measured dimensions of quality of life, whereas RBV treatment led to a decrease in the emotional and physical functioning. After treatment all dimensions for QOL showed improvement across the study cohort, regardless whether RBV was part of the treatment regimen However, 28.8%- 45.2% of treated patients perceive a sustained reduction in their physical or mental capacity after treatment, not related to RBV usage or SVR, but related to older age (p = 0.03) and cirrhosis (p = 0.02). Conclusions During treatment RBV leads to a reduced QOL, whereas RBV-free treatment leads to an increased QOL. After treatment, QOL strongly increases in both, RBV and RBV-free treated patients. Some patients perceived a sustained reduction in QOL, which seems unrelated to treatment. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/liv.13601

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