3 years ago

Back Cover: Double Asymmetric Hydrogenation of Linear β,β-Disubstituted α,β-Unsaturated Ketones into γ-Substituted Secondary Alcohols using a Dual Catalytic System (Chem. Eur. J. 37/2017)

Back Cover: Double Asymmetric Hydrogenation of Linear β,β-Disubstituted α,β-Unsaturated Ketones into γ-Substituted Secondary Alcohols using a Dual Catalytic System (Chem. Eur. J. 37/2017)
Hironori Satoh, Ryo Komatsu, Takeshi Ohkuma, Noriyoshi Arai
A dual asymmetric catalyst system realizes double hydrogenation of linear β,β-disubstituted α,β-unsaturated ketones into γ-substituted secondary alcohols with high diastereo- and enantioselectivities. This system is designed to reversibly form two hydrogenation catalyst types: (I) and (II). Type (I) bears a diamine ligand DMAPEN, and selectively hydrogenates the enone substrates into chiral allylic alcohols, whereas type (II) lacks the diamine ligand and preferentially reduces the alkenyl groups of the allylic alcohols. More information can be found in the Communication by T. Ohkuma et al. on page 8806.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701744

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