3 years ago

Frontispiece: A New Potent Inhibitor of Glycogen Phosphorylase Reveals the Basicity of the Catalytic Site

Frontispiece: A New Potent Inhibitor of Glycogen Phosphorylase Reveals the Basicity of the Catalytic Site
Thanasis Gimisis, Alessandro Venturini, Michael Mamais, Filippo Monti, Thomas Gustavsson, Virginia Kouloumoundra, Dimitra Markovitsi, Alessandra Degli Esposti, Evangelia D. Chrysina
Glycogen phosphorylase (GP) plays a key role in glucose regulation. The design and synthesis of a new potent inhibitor of GP is described. By exploiting its optical properties, it is shown that, due to an extended hydrogen bonding network, the local pH in the GP catalytic site is higher than 12. For the full story, see the Communication by A. Venturini, E. D. Chrysina, D. Markovitsi, T. Gimisis et al. on page 8800 ff.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201783763

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