ACS Catalysis
ACS Catalysis
5 years ago

Direct Allylic C–H Bond Activation To Synthesize [Pd(η3-cin)(IPr)Cl] Complex: Application in the Allylation of Oxindoles

Direct Allylic C–H Bond Activation To Synthesize [Pd(η3-cin)(IPr)Cl] Complex: Application in the Allylation of Oxindoles
Chun-Hai Wang, Shang-Dong Yang, Rong-Bin Hu, Zhong Liu, Wei Ren
N-heterocyclic carbenes (NHCs) was uncovered as an efficient ligand in promoting allylic C–H bond functionlizations. Notably, the catalytic [Pd(η3-cin)(IPr)Cl] complex (where cin = cinnamyl) was formed in situ from direct C–H activation of allylic precursors, and was obtained by way of one-pot strategy with available IPr·HCl and allylbenzene. The catalyst exhibits high regioselectivity and stereoselectivity of the allylic C–H alkylation with oxindoles with a broad scope.

Publisher URL: http://dx.doi.org/10.1021/acscatal.7b02965

DOI: 10.1021/acscatal.7b02965

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