3 years ago

Anticancer Activity of Iridium(III) Complexes Based on a Pyrazole-Appended Quinoline-Based BODIPY

Anticancer Activity of Iridium(III) Complexes Based on a Pyrazole-Appended Quinoline-Based BODIPY
Roop Shikha Singh, Daya Shankar Pandey, Shaikh M. Mobin, Sujay Mukhopadhyay, Vinay Sharma, Rajendra Prasad Paitandi
Syntheses and characterization of a novel pyrazole-appended quinoline-based 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (L1, BODIPY) and its cationic iridium(III) complexes [Ir(phpy)2(L1)]PF6 (1; phpy = 2-phenylpyridine) and [(η5-C5Me5)Ir(L1)Cl]PF6 (2) have been presented. Efficient binding of these complexes with DNA and protein have been established by various spectroscopic and molecular docking studies. Cytotoxicity, morphological changes, and apoptosis have been explored by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and Hoechst 33342 staining. Because of the inherent emissive nature of the BODIPY moiety, these are apt for intracellular visualization at low concentration and may find potential applications in cellular imaging and act as a theranostic agent.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.7b01693

DOI: 10.1021/acs.inorgchem.7b01693

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