3 years ago

Design and Characterization of a PVLA-PEG-PVLA Thermosensitive and Biodegradable Hydrogel

Design and Characterization of a PVLA-PEG-PVLA Thermosensitive and Biodegradable Hydrogel
Frank S. Bates, Alon V. McCormick, Timothy R. Pearce, Ajay Vidyasagar, Efrosini Kokkoli, Han Seung Lee, Mihee Kim, Minchul Kim, Sook Hee Ku
A set of poly(δ-valerolactone-co-d,l-lactide)-b-poly(ethylene glycol)-b-poly(δ-valerolactone-co-d,l-lactide) (PVLA-PEG-PVLA) triblock copolymers was synthesized and the solution properties were characterized using rheology, cryo-TEM, cryo-SEM, SANS, and degradation studies. This polymer self-assembles into a low viscosity fluid with flowerlike spherical micelles in water at room temperature and transforms into a wormlike morphology upon heating, accompanied by gelation. At even higher temperatures syneresis is observed. At physiological temperature (37 °C) the hydrogel’s average pore size is around 600 nm. The PVLA-PEG-PVLA gel degrades in about 45 days in cell media, making this unique hydrogel a promising candidate for biomedical applications.

Publisher URL: http://dx.doi.org/10.1021/acsmacrolett.7b00523

DOI: 10.1021/acsmacrolett.7b00523

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