3 years ago

A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation

Carlos López-Otín, Clea Bárcena

Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs.

Publisher URL: http://dx.doi.org/10.1038/ncb3602

DOI: 10.1038/ncb3602

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