A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation
Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs.
Publisher URL: http://dx.doi.org/10.1038/ncb3602
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