A caspase-independent way to kill cancer cells
Cancer treatments often focus on killing tumour cells through apoptosis, which is thought to typically require mitochondrial outer membrane permeabilization (MOMP) and subsequent caspase activation. A study now shows that MOMP can trigger TNF-dependent, but caspase-independent cell death, suggesting a different approach to improve cancer therapy.
Publisher URL: http://dx.doi.org/10.1038/ncb3604
DOI: 10.1038/ncb3604
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