4 years ago

Online Flowing Colloidosomes for Sequential Multi-analyte High-Throughput SERS Analysis

Online Flowing Colloidosomes for Sequential Multi-analyte High-Throughput SERS Analysis
Elizabeth Hui Zi Wee, In Yee Phang, Gia Chuong Phan-Quang, Fengling Yang, Xiaotong Feng, Ramón A. Alvarez-Puebla, Xing Yi Ling, Hiang Kwee Lee
3D plasmonic colloidosomes are superior SERS sensors owing to their high sensitivity and excellent tolerance to laser misalignment. Herein, we incorporate plasmonic colloidosomes in a microfluidic channel for online SERS detection. Our method resolves the poor signal reproducibility and inter-sample contamination in the existing online SERS platforms. Our flow system offers rapid and continuous online detection of 20 samples in less than 5 min with excellent signal reproducibility. The isolated colloidosomes prevent cross-sample and channel contamination, allowing accurate quantification of samples over a concentration range of five orders of magnitude. Our system demonstrates high-resolution multiplex detection with fully preserved signal and Raman features of individual analytes in a mixture. High-throughput multi-assay analysis is performed, which highlights that our system is capable of rapid identification and quantification of a sequence of samples containing various analytes and concentrations. Walking on Ag shells: Plasmonic colloidosomes are applied for the first time in a microfluidic channel for online SERS sensing of multiple samples. The high encapsulation efficiency of colloidosomes prevents inter-sample cross-talk and channel contamination, allowing the accurate quantification of samples with an analyte concentration range of five orders of magnitude.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201702374

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