Nanotechnology
Nanotechnology
5 years ago

Multiplex detection of pancreatic cancer biomarkers using a SERS-based immunoassay.

Sun, Foley, Houghton, Kim, Banaei
Early diagnosis of pancreatic cancer is critical to reduce the mortality rate of this disease. Current biological analysis approaches cannot robustly detect several low abundance pancreatic cancer biomarkers in sera, limiting the clinical application of these biomarkers. This study demonstrates a novel system for multiplex detection of pancreatic biomarkers CA19-9, MMP7 and MUC4 in sera samples with high sensitivity. Measuring the levels of these biomarkers in pancreatic cancer patients, pancreatitis patients, and healthy individuals reveals the unique expression pattern of these markers in pancreatic cancer patients, suggesting the great potential of using this approach for early diagnostics of pancreatic cancers.

Publisher URL: http://doi.org/10.1088/1361-6528/aa8e8c

DOI: 10.1088/1361-6528/aa8e8c

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