3 years ago

Total Synthesis of the Proposed Structure of (±)-Nidemone

Total Synthesis of the Proposed Structure of (±)-Nidemone
Chiao-Yun Cheng, Jen-Yu Yeh, Day-Shin Hsu
Total synthesis of the proposed structure of (±)-nidemone has been accomplished either from 2-hydroxy-6-methoxybenzaldehyde (7) or 2-bromo-6-methoxybenzaldehyde (8) in 10 and 13 synthetic steps, respectively. Sonogashira coupling, regioselective hydrogenation, and an intramolecular Stetter reaction were the key steps in the synthesis.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02645

DOI: 10.1021/acs.orglett.7b02645

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