5 years ago

Predictors of poor treatment outcomes in multidrug-resistant tuberculosis patients: A retrospective cohort study

We aimed to determine the characteristics, treatment outcomes and risk factors for poor treatment outcomes among multidrug-resistant tuberculosis (MDR-TB) patients in the Khyber Pakhtunkhwa province, Pakistan. Methods A retrospective cohort study including all patients with MDR-TB attended at the MDR-TB unit in Peshawar was conducted between January 2012 and April 2014. Patients were followed until an outcome of TB treatment was recorded as successful (cured or completed) or unsuccessful. Binary logistic regression was used to identify predictors of poor outcome i.e. unsuccessful treatment outcomes. Results Overall, 535 patients were included. The proportion of females was relatively higher (n=304, 55.9%) than males. The mean age of patients was 30.37 (standard deviation (SD)=14.09) years. Out of 535 patients for whom treatment outcomes were available, 402 (75.14%) were cured, 4 (0.74%) completed, 34 (6.3%) failed, 93 (17.4%) died and 2 (0.4%) defaulted; in total, 129 (24.1%) had unsuccessful outcome. We found three significant predictors of unsuccessful treatment during multivariate logistic regression: being married (odds ratio (OR)=2.17, 95% CI. 1.01, 4.66), resistance to second line drugs (OR=2.61, 95% CI. 1.61, 4.21) and the presence of extensively drug-resistant tuberculosis (XDR-TB) (OR=7.82, 95% CI. 2.90, 21.07). Conclusions Around 75% of the treatment success rate set by the Global Plan to stop TB was achieved. Resistance to second line drugs and presence of XDR-TB are the main risk factors for poor treatment outcomes.

Publisher URL: www.sciencedirect.com/science

DOI: S1198743X17305256

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