Clinical Microbiology and Infection
Clinical Microbiology and Infection
5 years ago

Predictors of poor treatment outcomes in multidrug-resistant tuberculosis patients: A retrospective cohort study

We aimed to determine the characteristics, treatment outcomes and risk factors for poor treatment outcomes among multidrug-resistant tuberculosis (MDR-TB) patients in the Khyber Pakhtunkhwa province, Pakistan. Methods A retrospective cohort study including all patients with MDR-TB attended at the MDR-TB unit in Peshawar was conducted between January 2012 and April 2014. Patients were followed until an outcome of TB treatment was recorded as successful (cured or completed) or unsuccessful. Binary logistic regression was used to identify predictors of poor outcome i.e. unsuccessful treatment outcomes. Results Overall, 535 patients were included. The proportion of females was relatively higher (n=304, 55.9%) than males. The mean age of patients was 30.37 (standard deviation (SD)=14.09) years. Out of 535 patients for whom treatment outcomes were available, 402 (75.14%) were cured, 4 (0.74%) completed, 34 (6.3%) failed, 93 (17.4%) died and 2 (0.4%) defaulted; in total, 129 (24.1%) had unsuccessful outcome. We found three significant predictors of unsuccessful treatment during multivariate logistic regression: being married (odds ratio (OR)=2.17, 95% CI. 1.01, 4.66), resistance to second line drugs (OR=2.61, 95% CI. 1.61, 4.21) and the presence of extensively drug-resistant tuberculosis (XDR-TB) (OR=7.82, 95% CI. 2.90, 21.07). Conclusions Around 75% of the treatment success rate set by the Global Plan to stop TB was achieved. Resistance to second line drugs and presence of XDR-TB are the main risk factors for poor treatment outcomes.

Publisher URL: www.sciencedirect.com/science

DOI: S1198743X17305256

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.