Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

General Approaches to Structurally Diverse Isocyanoditerpenes

General Approaches to Structurally Diverse Isocyanoditerpenes
Mary Elisabeth Daub, Philipp C. Roosen, Christopher D. Vanderwal
Since their discovery in the 1970s, the striking architectures and the unusual isonitrile functional groups of the isocyanoterpenes have attracted the interest of many organic chemists. The more recent revelation of their potent in vitro antiplasmodial activity sparked new endeavors to synthesize members of this family of secondary metabolites. In this Synopsis, we discuss three distinct strategies that each address multiple structurally different members of the isocyanoterpenes, ending with some of our group’s recent contributions in this area.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00448

DOI: 10.1021/acs.joc.7b00448

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