Journal of Agricultural and Food Chemistry
Journal of Agricultural and Food Chemistry
3 years ago

[ASAP] Usefulness of Hybrid Magnetoliposomes for Aminoglycoside Antibiotic Residues Determination in Food Using an Integrated Microfluidic System with Fluorometric Detection

[ASAP] Usefulness of Hybrid Magnetoliposomes for Aminoglycoside Antibiotic Residues Determination in Food Using an Integrated Microfluidic System with Fluorometric Detection
Ángela Écija-Arenas, Vanesa Román-Pizarro, Juan Manuel Fernández-Romero
A new microfluidic approach using hybrid magnetoliposomes (h-MLs) containing hydrophobic magnetic nanoparticles (Fe3O4@AuNPs-C12SH) and encapsulated N-acetylcysteine has been developed in this research to determine aminoglycoside antibiotic (AAG) residues in food using o-phthalaldehyde. Four AAGs, kanamycin, streptomycin, gentamicin, and neomycin, have been used as model analytes. The h-MLs have been used for reagent preconcentration and were retained using an external electromagnet device in the reaction/detection zone in a microfluidic system, inserted into the sample chamber of a conventional fluorimeter. The formation of a fluorescent isoindole derivate caused an increase in the luminescence signal, which was proportional to the analyte concentration. The dynamic range of the calibration graph was 0.1–1000 μmol L–1, expressed as AAG concentration, with an 8.7 nmol L–1 limit of detection for kanamycin and a sampling frequency of 8 h–1. The method was applied to determine AAG residues in milk and meat samples with recovery values between 87.2 and 107.4%. This article has not yet been cited by other publications.

Publisher URL: http://feedproxy.google.com/~r/acs/jafcau/~3/Z94xr-FT5_s/acs.jafc.1c01571

DOI: 10.1021/acs.jafc.1c01571

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