3 years ago

Calcium Signaling and Transcriptional Regulation in Cardiomyocytes.

Dewenter, Backs, von der Lieth, Katus
Calcium (Ca(2+)) is a universal regulator of various cellular functions. In cardiomyocytes, Ca(2+) is the central element of excitation-contraction coupling, but also impacts diverse signaling cascades and influences the regulation of gene expression, referred to as excitation-transcription coupling. Disturbances in cellular Ca(2+)-handling and alterations in Ca(2+)-dependent gene expression patterns are pivotal characteristics of failing cardiomyocytes, with several excitation-transcription coupling pathways shown to be critically involved in structural and functional remodeling processes. Thus, targeting Ca(2+)-dependent transcriptional pathways might offer broad therapeutic potential. In this article, we (1) review cytosolic and nuclear Ca(2+) dynamics in cardiomyocytes with respect to their impact on Ca(2+)-dependent signaling, (2) give an overview on Ca(2+)-dependent transcriptional pathways in cardiomyocytes, and (3) discuss implications of excitation-transcription coupling in the diseased heart.

Publisher URL: http://doi.org/10.1161/CIRCRESAHA.117.310355

DOI: 10.1161/CIRCRESAHA.117.310355

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