Accounts of Chemical Research
Accounts of Chemical Research
4 years ago

Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery

Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery
Kelly Chibale, John Okombo
New, safe and effective drugs are urgently needed to treat and control malaria and tuberculosis, which affect millions of people annually. However, financial return on investment in the poor settings where these diseases are mostly prevalent is very minimal to support market-driven drug discovery and development. Moreover, the imminent loss of therapeutic lifespan of existing therapies due to evolution and spread of drug resistance further compounds the urgency to identify novel effective drugs. However, the advent of new public–private partnerships focused on tropical diseases and the recent release of large data sets by pharmaceutical companies on antimalarial and antituberculosis compounds derived from phenotypic whole cell high throughput screening have spurred renewed interest and opened new frontiers in malaria and tuberculosis drug discovery.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.6b00631

DOI: 10.1021/acs.accounts.6b00631

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